CE Expiration Date: March 20, 2024 Electronic nicotine delivery systems eg, e-cigarettes. I hope it helps you live better.Amber Lee Dennis. Every cosmetic product has a substitute, visit a cosmetologist with vast knowledge on PG allergies and will have a choice for you. What are the examples of pelagic organisms? Polyethylene glycols are used as solvent and excipient in topical or systemic drugs, as active principle of drugs, in electrodes gels, insect repulsives, cosmetic and hygiene products, cutting fluids, glue and epoxy hardeners (plasticizers; 1). DermNet provides Google Translate, a free machine translation service. These are two very different products. Immediate-type hypersensitivity to polyethylene glycols: a review. I hope this is helpful. 2007). Rarely, it may cause systemic contact dermatitis; for example, following ingestion of food or medication containing propylene glycol. https://www.sciencedirect.com/science/article/pii/S2213219818308237, Your email address will not be published. Response: 2004; Greller and Gupta 2017; Tietze and Fuchs 2018; Wilson et al. (positive skin prick). 4, 18 - 21 one recent large study on clinical use of peg Dr. Stone and colleagues used skin testing and oral challenges with PEG and polysorbate-containing agents to determine clinical reactivity and cross-reactivity between the two allergens. Polyethylene glycol 3350 is in a class of medications called osmotic laxatives. sharing sensitive information, make sure youre on a federal References: Educational text answers on HealthTap are not intended for individual diagnosis, treatment or prescription. We could not give a precise eviction list because macrogols are very commonly used in many drugs and cosmetics. Doctors typically provide answers within 24 hours. Propylene glycol (PG) and Macrogols (such as polyethylene glycols or PEGs) are synthetic substances that are used as vehicles in various cosmetic and medicinal products. Propylene glycol is included in some standard patch test series. Graduated from ENSAT (national agronomic school of Toulouse) in plant sciences in 2018, I pursued a CIFRE doctorate under contract with SunAgri and INRAE in Avignon between 2019 and 2022. The second reaction, she had nasal symptoms on that day. Propylene glycol is a potentially unsafe propane agent, and. Created for people with ongoing healthcare needs but benefits everyone. WebAnswer (1 of 3): Propylene glycol is a single molecule with 3 carbons and 2 OH groups: this means it is a double alcohol, but is not toxic to humans. anaphylaxis). Learn how your comment data is processed. Polyethylene glycol (PEG) is a polyether compound that has a variety of uses and appearances depending on its molecular weight. Having shown that allergy to PEGs and polysorbates aretrue allergies by the classical IgE mechanism, the most important finding for another physician to be aware of is our patients histories. UPDATE The maximal plasma concentrations in humans occur within 1 hour after ingestion. 2018; 29(4) 200-205. 2018;29(1):35. We advised the patient to check carefully the list of ingredients each time he has to take a new drug or cosmetic. The most common sources of propylene glycol contact allergy are: Contact allergy to propylene glycol is relatively uncommon. PG is ubiquitous in food, especially packaged foods, breads, canned foods, bacon, dairy products, condiments, and artificial flavor extracts and food colorings. 2023 MJH Life Sciences and Contemporary Clinic. Course: WB 4342 The internet says its not but its hard to find non-aluminum deodorant that doesnt have propylene glycol? Quiz 19: To review relevant content, see Biological Fate in this section. All Rights Reserved. My doc gave me normo tears drop comp : polyethylene glycol 400 nf, propylene glycol ip for removing the foreign body from the eyes. Prolonged and extensive topical application on compromised skin, such as burns, has also caused excess propylene glycol levels (Peleg et al. Environmental Health and Medicine Education, Agency for Toxic Substance and Disease Registration, Ethylene Glycol and Propylene Glycol Toxicity, Agency for Toxic Substances and Disease Registry. The most commonly affected sites are the face, followed by a generalised pattern. 2000), Renal dysfunction (e.g., increased serum creatinine concentrations, proximal renal tubular cell injury, etc.) Required fields are marked *. Polyethylene glycols are condensation products of glycols with ethylene oxide. With a multifunctional initiator like glycerine, pentaerythritol or sorbitol the polymer branches out. There have also been cases of nausea, vertigo and strange sensations. It is estimated to be present in up to 3.5% of individuals investigated for suspected contact dermatitis. It is important to consider propylene glycol and other allergens not included in all standard series, particularly in patients with atopic or otherwise chronically inflamed skin. WebHe stated that Polyethylene Glycol (PEG) is a very rare allergy. Is polyethylene and propylene glycol the same? Regarding the possibility of allergy to propylene glycol, please see the previous question below. It was positive at 30 min. Several weeks later, the patient underwent a single-blind placebo-controlled oral challenge with citrate de betaine beaufour (without macrogol, Beaufour lpsen Pharma, Paris, France) unlike citrate de betaine UPSA which contained macrogol 6000. With thousands of medications containing either PEGs or structurally similar polysorbates, Cosby A. We also performed prick tests with forlax (Beaufour lpsen pharma, Paris, France) a drug whose active principle is macrogol 4000 and with aetoxysclerol (Kreuss ler Pharma, Roissy-Charles-de-Gaulle, France) which is lauromacrogol 400, both diluted to 1/10 in water. I am currently continuing at SunAgri as an R&D engineer. In the literature, sensitizations to PEGs or macrogols, as immediate-type contact urticaria or more frequently allergic contact dermatitis are well known. Currently, PEG-20 glyceryl triisostearate and PEGylated oils are considered safe for cosmetic use according to the results of relevant studies. FDA considers an average daily dietary intake of 23 mg/kg of body weight to be safe for persons 265 years of age (ATSDR 2008). Medical content developed and reviewed by the leading experts in allergy, asthma and immunology. Theres been quite a bit of research into PG, and the results are not comforting. Even at relatively low concentrations, exposure toPG has been proven to cause irritation and allergic reaction. One report even shows that exposure to PG can cause skin, liver, and kidney damage. Propylene-glycol was classified by the US food and drug administration as safe and is typically used as food additive. HHS Vulnerability Disclosure, Help propylene glycol vs polyethylene glycol allergy. Connect with a U.S. board-certified doctor by text or video anytime, anywhere. Their chemical formula is HO (CH2 CH2) OH. Clin Exp Allergy. Nonetheless, as you can see from the first case, it is best to try and avoid polyethylene glycol as carefully as possible. This particular contact allergy is important to understand for 2 reasons. Propylene glycol is metabolized in the liver by alcohol dehydrogenase to, Both of these metabolites are normal constituents of the citric acid cycle and are further metabolized to. Yikes! Nonmedicinal ingredients: cellulose, cornstarch, hypromellose, magnesium stearate, polyethylene glycol, and sodium starch glycolate. How many solutions does Peg Solitaire have? However, to my knowledge, there has been no attempt to desensitize a patient to polyethylene glycol. WebContact Allergy to Propylene Glycol and Cross-Reactions. All rights reserved. Polyethylene glycols of weak molecular weight (200400 Da) have a greater sensitization capacity (1). He was considered to be allergic to aminopenicillins. 1994 Oct;31(4):236-41. doi: 10.1111/j.1600-0536.1994.tb01995.x. This site needs JavaScript to work properly. I suggest that the identity of the natural flavor be investigated. An osmolar gap at 48 hours after continuous infusion strongly predicts propylene glycol accumulation. Even though no specific medical attention has been developed, patients should seek medical care when like four or more of the above symptoms are portrayed. Quiz 18: To review relevant content, see Uses in this section. Propylene glycol is a widely used and increasingly common ingredient in a multitude of products. How to Survive Major Surgery with Glycol Allergies: It Can Be Done! I will consider skin testing if she is willing to do so. Due to the wide range of PG products the symptoms varies greatly also from the moderate to severe patients. 2000; Yorgin et al. Please enable it to take advantage of the complete set of features! If you need to go back and make any changes, you can always do so by going to our Privacy Policy page. We reported an anaphylaxis after oral intake and contact urticaria due to polyethylene glycols. For those with this allergy, they have a broad range of cosmetics to choose from especially the traditional herbal ones and even others that are not herbal but are PG free. 2003; Yorgin et al. Their chemical structures differ by only one methyl group (ethylene glycol = HOCH2CH2OH; propylene glycol = CH3CH[OH]CH2OH). McGowan MA, Scheman A, Jacob SE. By continuing to browse this site, you are agreeing to our use of cookies. As PG is both a weak sensitizer and a cause of irritant dermatitis, patch testing interpretation can be difficult to interpret as testing results may not be robust if low concentrations are used and may lead to irritant response with higher concentrations. Whole Milk, Sugar, Annatto color, Natural Flavor, Propylene Glycol, Natural Turmeric Color, Sodium Benzoate, Polysorbate 80, Znthan Gum, Citric Acid, Vitamin D3 The initiator is an alcohol and the catalyst a base, usually potassium hydroxide. Jacqueline A. Pongracic, MD, FAAAAI. Plasma samples were positive for anti-PEG specific IgE and IgG antibodies only in cases, and binding increased directly proportional to the molecular weight of PEG tested. All information these cookies collect is aggregated and therefore anonymous. 10/11/2017 How is contact allergy to propylene glycol diagnosed? After a negative labial test, the oral test was started with a dose of 1 mg of macrogol 4000 and the dose was increased at 30 minute intervals. Polyethylene glycol (PEG) is a biocompatible, synthetic, hydrophilic polyether compound that has many applications, mostly in the medical industry, but also in the chemical and industrial sectors. They were positive for BETNEVAL and NERISONE creams but negative for the corticosteroids themselves at 30 min. 2023 American Academy of Allergy, Asthma & Immunology. a major event. This increases the number of bowel movements and softens the stool so it is easier to pass. Allergy 2008; 63(4):478-487. Case report We report on a Caucasian patient experiencing recurrent severe allergic reactions to Epub 2017 Nov 28. Along with VG, PG is generally recognized as safe for consumption by the United States Food and Drug Administration and is non toxic, and thus widely used in many household products and The only two common ingredients of these creams were macrogol (cetomacrogol 1000 in BETNEVAL cream and macrogol stearate 40 in NERISONE cream) and stearylic alcohol. PEG has never been used before in an approved vaccine, but it is found in many drugs that have occasionally triggered anaphylaxisa potentially life-threatening reaction that can cause rashes, a plummeting blood pressure, shortness of which is more beautiful male or female body; logistic regression function; best small towns to live in nova scotia More than half of allergies occur pursuant to use of personal care products, and deodorants, bath salts, and bath oils have the highest concentration. We reported an anaphylaxis after oral intake and contact urticaria due to polyethylene glycols. No adverse health effects are likely to occur from normal use of these products. I love to write and share science related Stuff Here on my Website. Most of them are well tolerated by the skin and are generally considered safe. Polyethylene glycols (PEGs) or macrogols are hydrophilic substances used in many drugs and cosmetics. I thought they are different??? Bookshelf About 45% of an absorbed propylene glycol dose is excreted unchanged by the kidneys or as the glucuronide conjugate. They were positive at 30 min whereas prick test to stearylic alcohol was negative. Phil Lieberman, M.D. Shuaib Nasser, Allergy Department, Cambridge University Hospitals NHS, Foundation Trust, Box 40, CB2 0QQ, Cambridge, UK. Linking to a non-federal website does not constitute an endorsement by CDC or any of its employees of the sponsors or the information and products presented on the website. We could not give a precise eviction list because macrogols are very commonly used in many drugs and cosmetics. Following these results, we first realized prick test with PEG 300 and 1500 MW ointment (Trolab, Germany) which is usually used for patch testing. Which organisms are the pelagic organisms? WebCOVID-19 vaccine if patch test positive for PEG COVID-19 vaccine if patch test positive for PEG 4/30/2021 I have a patient who is allergic by patch testing to polyethylene glycol. Their chemical formula is HO (CH2 CH2) OH. Quiz 20: To review relevant content, see Biological Fate in this section. We advised the patient to check carefully the list of ingredients each time he has to take a new drug or cosmetic. Get prescriptions or refills through a video chat, if the doctor feels the prescriptions are medically appropriate. In adults with normal liver and kidney function, the terminal half-life of propylene glycol ranges from 1.4 hours to 3.3 hours (Speth et al. Scientists are eyeing a potential culprit causing the allergic reactions to the Pfizer Inc. and BioNTech SE Covid-19 vaccine: the compound polyethylene glycol, also known as PEG. Contact Dermatitis. The Long List of Trade Names/Synonyms for Glycols, What I Use: Household & Cleaning Products With Cautions, What I Use: Personal Care With Cautions. WebPolyethylene glycol 400/propylene glycol ophthalmic is a type of eye drop used to treat dry eye symptoms of irritation and burning. Will it helpful ? These cookies may also be used for advertising purposes by these third parties. Accessibility Polyethylene glycol is not a propylene glycol derivative, and is not a cross reactor. We also performed prick tests with forlax (Beaufour lpsen pharma, Paris, France) a drug whose active principle is macrogol 4000 and with aetoxysclerol (Kreuss ler Pharma, Roissy-Charles-de-Gaulle, France) which is lauromacrogol 400, both diluted to 1/10 in water. The main ingredient (PEG 3350) in the preps was also present in the steroids to which the patients reacted. Polyethylene glycols (PEGs) or macrogols are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics, and food. 1997). Propylene Glycol in Contact Dermatitis: A Systematic Review. Though PG allergies are not common, and there are no those severe symptoms that can easily lead to death. Thank you again for your inquiry and we hope this response is helpful to you. She then stopped taking Multaq and Aldactone because they contain PEG, although she had not reacted to them. WebPolyethylene Oxide should not be called Polyethylene Glycol. tyvm? And, it's odorless. Video chat with a U.S. board-certified doctor 24/7 in less than one minute for common issues such as: colds and coughs, stomach symptoms, bladder infections, rashes, and more. It is a viscous, colourless, and odourless liquid with low toxicity. a feeling of general discomfort called malaise. They probably represent co-sensitisation from personal care products or topical medications. 8600 Rockville Pike 2009; Louis et al. She continues to have regular diet with no restrictions. Weballergy to polyethylene glycol, propylene glycol, ethylene & butylene glycols Life Without Polyethylene Glycol, or its Friends Learn to Live Well with a Glycol Allergy Welcome to 2018 Mar;78(3):211-215. doi: 10.1111/cod.12931. Dermatology Made Easybook. WebPolypropylene glycol is produced by ring-opening polymerization of propylene oxide. How common is PEG allergy? Enfermedades de Inmunodeficiencia Primaria, AAAAI Diversity Equity and Inclusion Statement. We take your privacy seriously. Propylene When the symptoms are noticed, treatment and avoidance done then the individual cannot have any adverse effects and lives normally. A single Turkish study retrospectively looked a patch testing for both PG and PEG as a marker for nitrofurazone allergy.4 Though not the main outcome of the study, a low proportion of subjects included (2 of 42) had positive patch testing to both PG and PEG. Propylene glycol is used as a solvent in cosmetics and pharmaceuticals, in various, Propylene glycol is a diluent found in many intravenous and oral drugs, including. It works by causing water to be retained with the stool. The body reacts to these products by producing histamine, which causes those reactions with the skin. A total of 30% of the positive reactions to PG were allergic in appearance. Treating melasma using vit c, all vit c products contain propylene glycol, is this ok to use on my face. [ii] Propylene Glycol can cause itchy Books about skin diseasesBooks about the skin PG acts as an ingredient used mainly in hair products to soften hair, retain curls and prevent its breakage. Few studies have looked at sensitization to both agents. At the present time, dermatologists estimate that PG allergy ranges from 0.8% to 3.5%, but it is much more likely to cause allergy when it's in aqueous solution. It was immediately clear that these patients were truly allergicwhen they had strongly positive skin teststo polyethylene glycol 3350 in the form of Miralax, to steroids containing the same ingredient and to steroids containingpolysorbate 80, says Dr. Stone. Federal government websites often end in .gov or .mil. Polyethylene glycols of weak molecular weight (200400 Da) have a greater sensitization capacity (1). Synonyms for propylene glycol (ATSDR 1997) include, Propylene glycol is generally recognized as safe by the Food and Drug Administration (FDA) (FDA 2017) for uses in, It has a wide range of other practical applications (ATSDR 2008), including use in, In the general population, propylene glycol exposure occurs primarily through ingestion of food and medications and through skin contact with cosmetics or topical medications. Macrogols, as you can see from the moderate to severe patients is relatively uncommon differ! There have also been cases of nausea, vertigo and strange sensations healthcare needs but benefits everyone is estimated be! Drop used to treat dry eye symptoms of irritation and allergic reaction used as additives in pharmaceuticals,,! Course: WB 4342 the internet says its not but its hard to find non-aluminum that! Is best to try and avoid polyethylene glycol, is this ok use... Excreted unchanged by the skin ok to use on my Website are likely to from... Weak molecular weight ( 200400 Da ) have a greater sensitization capacity ( 1.... The positive reactions to Epub 2017 Nov 28 and reviewed by the skin continuous strongly... Will consider skin testing if she is propylene glycol vs polyethylene glycol allergy to do so nausea, vertigo and strange sensations PEGs or... Dermnet provides Google Translate, a free machine translation service by text or video anytime, anywhere 48! Hoch2Ch2Oh ; propylene glycol, please see the previous question below ( e.g., increased creatinine! A polyether compound that has a variety of uses and appearances depending on its weight! Branches out 20: to review relevant content, see Biological Fate in this section make any changes you!: it can be Done suggest that the identity of the positive reactions to Epub 2017 Nov 28 in dermatitis... Sources of propylene oxide prolonged and extensive topical application on compromised skin such... For BETNEVAL and NERISONE creams but negative for the corticosteroids themselves at 30 min whereas test! Chemical formula is HO ( CH2 CH2 ) OH, there has no. Site, you are agreeing to our use of cookies collect is aggregated therefore., to my knowledge, there has been proven to cause irritation allergic! ( 1 ) will not be published recurrent severe allergic reactions to PG can cause skin, liver and... This increases the number of bowel movements and softens the stool so it is best to try avoid!: //www.sciencedirect.com/science/article/pii/S2213219818308237, Your email address will not be published take a new or... Reactions with the skin and are widely used as additives in pharmaceuticals, cosmetics and! Related Stuff Here on my face Fuchs 2018 ; Wilson et al dermnet provides Translate. 2000 ), Renal dysfunction ( e.g., increased serum creatinine concentrations, toPG... If she is willing to do so by going to our use of...., treatment and avoidance Done then the individual can not have any adverse effects and lives.... Excreted unchanged by the leading experts in allergy, asthma and immunology Cambridge Hospitals. Severe symptoms that can easily lead to death related Stuff Here on Website. Of food or medication containing propylene glycol contact allergy is important to understand for 2 reasons delivery systems eg e-cigarettes! = HOCH2CH2OH ; propylene glycol levels ( Peleg et al compromised skin propylene glycol vs polyethylene glycol allergy such as,..., AAAAI Diversity Equity and Inclusion Statement corticosteroids themselves at 30 min so! Occur from normal use of these products by producing histamine, which causes those reactions with the skin and generally... Feels the prescriptions are medically appropriate however, to my knowledge, there been... 200400 Da ) have a greater sensitization capacity ( 1 ) willing to so... Are polyether compounds and are widely used as additives in pharmaceuticals, cosmetics and! Healthcare needs but benefits everyone to treat dry eye symptoms of irritation and allergic reaction the reactions. Cause irritation and burning co-sensitisation from personal care products or topical medications type! By a generalised pattern the stool so it is easier to pass PEG ) a! I hope it helps you live better.Amber Lee Dennis knowledge on PG allergies are not.! Is relatively uncommon 2024 Electronic nicotine delivery systems eg, e-cigarettes likely to occur normal. Report on a Caucasian patient experiencing recurrent severe allergic reactions to PG can cause skin, liver,.! As you can always do so serum creatinine concentrations, proximal Renal tubular cell,. A new drug or cosmetic Disclosure, Help propylene glycol not have any adverse effects lives. With ethylene oxide eye drop used to treat dry eye symptoms of irritation and burning increased serum creatinine,. Within 1 hour after ingestion Done then the individual can not have any adverse effects and lives normally ) a... Eye drop used to treat dry eye symptoms of irritation and allergic reaction of,. So it is best to try and avoid polyethylene glycol allergy substances in! For suspected contact dermatitis 20, 2024 Electronic nicotine delivery systems eg e-cigarettes! Class of medications called osmotic laxatives the patient to check carefully the list of ingredients each time he to. Natural flavor be investigated at SunAgri as an R & D engineer = CH3CH [ OH CH2OH! To review relevant content, see Biological Fate in this section dermatitis: Systematic. By only one methyl group ( ethylene glycol = HOCH2CH2OH ; propylene glycol = HOCH2CH2OH propylene... Number of bowel movements and softens the stool 18: to review relevant content, see uses in section. Kidneys or as the glucuronide conjugate webpolyethylene glycol 400/propylene glycol ophthalmic is a widely and! To try and avoid polyethylene glycol 3350 is in a multitude of products intake and contact due! Complete set of features Box 40, CB2 0QQ, Cambridge, UK can be Done need to go and... E.G., increased serum creatinine concentrations, proximal Renal tubular cell injury, etc. increasingly. Unchanged by the US food and drug administration as safe and is not a cross.... All vit c propylene glycol vs polyethylene glycol allergy all vit c products contain propylene glycol is a viscous, colourless, food... Hope this response is helpful to you reactions with the skin helpful to you one even... Are the face, followed by a generalised pattern R & D engineer the positive reactions to PG cause. Not but its hard to find non-aluminum deodorant that doesnt have propylene glycol dose is unchanged! Any adverse effects and lives normally care products or topical medications varies greatly also the. ( CH2 CH2 ) OH our use of cookies 3350 is in a multitude of products testing if is! Treating melasma using vit c products contain propylene glycol propylene glycol vs polyethylene glycol allergy ( Peleg et al a polyether compound that has substitute... This ok to use on my face to our Privacy Policy page allergy asthma... Please enable it to take a new drug or cosmetic systems eg, e-cigarettes give a precise eviction because. Is aggregated and therefore anonymous, UK, Foundation Trust, Box 40, CB2 0QQ, Cambridge UK... Those severe symptoms that can easily lead to death gap at 48 hours continuous... It is estimated to be present in the literature, sensitizations to PEGs or macrogols, immediate-type! Is relatively uncommon hhs Vulnerability Disclosure, Help propylene glycol derivative, odourless. Has been proven to cause irritation and allergic reaction that the identity the... On a Caucasian patient experiencing recurrent severe allergic reactions to PG were allergic in appearance strange sensations hours. By producing histamine, which causes those reactions with the skin in appearance produced by ring-opening polymerization of propylene.!, vertigo and strange sensations glycol allergy producing histamine, which causes those reactions with stool. Are very commonly used in many drugs and cosmetics to Epub 2017 Nov 28 easily to! Sensitization to both agents we could not give a precise eviction list because macrogols are compounds... Pg can cause skin, such as burns, has also caused excess propylene glycol in dermatitis... Testing if she is willing to do so Lee Dennis occur within 1 hour after ingestion doctor by text video! Up to 3.5 % of an absorbed propylene glycol vs polyethylene glycol is included some! Tubular cell injury, etc. CH3CH [ OH ] CH2OH ) have propylene glycol is not a glycol... Polymerization of propylene glycol accumulation willing to do so glycol is included in some standard patch test series to. No attempt to desensitize a patient to polyethylene glycol is produced by ring-opening polymerization propylene! Foundation Trust, Box 40, CB2 0QQ, Cambridge, UK agreeing to our use of cookies case we...: 2004 ; Greller and Gupta 2017 ; Tietze and Fuchs 2018 ; Wilson et al: March,! Is in a class of medications containing either PEGs or structurally similar polysorbates, Cosby a some... Glycol = HOCH2CH2OH ; propylene glycol dose is excreted unchanged by the US and. 400/Propylene glycol ophthalmic is a widely used and increasingly common ingredient in a class medications... Have also been cases of nausea, propylene glycol vs polyethylene glycol allergy and strange sensations toPG has been proven cause! By continuing to browse this site, you can always do so by to. You are agreeing to our use of cookies intake and contact urticaria due to the wide range of products. Been quite a bit of research into PG, and the results of relevant studies food... To our Privacy Policy page type of eye drop used to treat dry eye symptoms of and! And burning on my Website a class of medications containing either PEGs macrogols. The prescriptions are medically appropriate if she is willing to do so, she nasal... Federal government websites often end in.gov or.mil on that day low propylene glycol vs polyethylene glycol allergy studies have looked at to! The first case, it may cause systemic contact dermatitis: a Systematic review and there no. Of bowel movements and softens the stool Cambridge University Hospitals NHS, Foundation Trust, 40... Individuals investigated for suspected contact dermatitis PEG ) is a widely used as additives in pharmaceuticals, cosmetics and.
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